SMER3 , CAS 67200-34-4

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Applications: Useful for the inhibition of SCFMET30 in cell-based or in vitro assays.

CAS Number: 67200-34-4

Description: Small Molecule Enhancer of Rapamycin 3 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SCFMET30. SMER3 binds directly to the F-box subunit Met30 and blocks binding to the SCF core complex. Cell permeable. Significant inhibition is typically seen at 30-100 µM.

Format: Yellow powder

Purity: >98% by TLC.

Solubility: Soluble in DMSO (up to 20 mg/ml, with heating)

Storage Stability: Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 2 months.

Warnings: Protect from moisture.

Biosafety Level: Not applicable (BSL-1)

References: 1. Aghajanyy, M. et al. Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat. Biotech. 2010, 28(7):738.

• SKU: BPS27718-2
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 27718-2
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK