Formulation: A solid
Formal Name: 3β,5β,14-trihydroxy-19-oxo-card-20(22)-enolide
Purity: ≥90%
Formula Markup: C23H32O6
Formula Weight: 404,5
Shelf life (days): 1460
CAS Number: 66-28-4
Notes: Strophanthidin is a cardenolide that has been found in A. schimperi and has diverse biological activities.{41362,42765,25457,65940} It is an inhibitor of N-acetyltransferase (IC50 = ~1.2 µM).{41362} Strophanthidin (1 µM) reduces maximal Na+/K+-ATPase pump activity and cell attachment and increases cell death in MDCK-C7 cells.{42765} It decreases the levels of steroid receptor coactivator 3 (SRC-3) in MCF-7 breast cancer cells when used at a concentration of 500 nM.{25457} Strophanthidin (50 µM) increases calcium efflux and sarcoplasmic reticulum calcium levels in a voltage-clamp assay using isolated and perfused guinea pig hearts.{65940}
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