Product Description: SU 5402 (GMP) is SU 5402 (HY-10407) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGFRβ, respectively[1].
Applications: Cancer-Kinase/protease
Formula: C17H16N2O3
References: [1]Zeng H, et al. Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells. PLoS One. 2010 Jul 29;5(7):e11853. /[2]Nishihara K, et al. Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression. Stem Cell Reports. 2019 Feb 12;12(2):305-318. /[3]Ito A, et al. Efficient and robust induction of retinal pigment epithelium cells by tankyrase inhibition regardless of the differentiation propensity of human induced pluripotent stem cells. Biochem Biophys Res Commun. 2021 May 7;552:66-72. /[4]Chambers SM, et al. Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat Biotechnol. 2012 Jul 1;30(7):715-20.
CAS Number: 215543-92-3
Molecular Weight: 296.32
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: EGFR;PDGFR;VEGFR
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