Formulation: A solid
Formal Name: 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-benzenesulfonamide-d4
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C12H10D4N4O4S
Formula Weight: 314,4
Shelf life (days): 1460
CAS Number: 1330266-05-1
Notes: Sulfadoxin-d4 is intended for use as an internal standard for the quantification of sulfadoxin (Item No. 21488) by GC- or LC-MS. Sulfadoxin is a sulfonamide antibiotic that inhibits dihydropteroate synthetase (DHPS), an enzyme involved in folic acid (Item No. 20515) synthesis.{34630} Sulfadoxin competes with 4-aminobenzoate (PABA), the native substrate of DHPS, and inhibits PABA incorporation into folic acid.{34631} Folate is essential for purine and pyrimidine synthesis, therefore, sulfadoxin has antiproliferative activity in non-resistant P. falciparum.{34631,34632} Sulfadoxin inhibits growth of P. falciparum in vitro, but potency varies between non-resistant (IC50 = 4 ng/ml) and resistant strains (IC50 = 3,970 ng/ml).{34632}
English
Deutsch
