Sulfonadyn-47

Formulation: A solid

Formal Name: (E)-N-(3-((3-(4-bromophenyl)allyl)amino)propyl)naphthalene-1-sulfonamide

Purity: ≥98%

Formula Markup: C22H23BrN2O2S

Formula Weight: 459,4

Shelf life (days): 1095

Notes: Sulfonadyn-47 is a dynamin inhibitor.{71044} It inhibits dynamin GTPase activity in a cell-free assay (IC50 = 3.5 µM). Sulfonadyn-47 inhibits clathrin-mediated endocytosis in U2OS cells (IC50 = 27.3 µM), as well depolarization-stimulated uptake of FM4-64, a marker of synaptic vesicle endocytosis (SVE), in isolated rat brain synaptosomes (IC50 = 12.3 µM). In vivo, sulfonadyn-47 (30 and 60 mg/kg) has anticonvulsant activity in the 6 Hz corneal kindling mouse model of seizures.

• SKU: CAY39402-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39402-500
• Green Labware: No
• Package Unit: 500 µg
• Quantity Unit: STK