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Biological Activity: Telotristat has been reported to inhibit the TPH enzyme. This inhibition can reduce serotonin production in the periphery.
CAS Number: 1033805-28-5
Description: Telotristat is the active metabolite of LX1606 (Telotristat etiprate), which is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
Purity: ≥98%
Solubility: Soluble in DMSO (10 mM). Only sparingly soluble in water (<1.5 µg/ml).
Storage Stability: Store as supplied at or below -20°C for up to 2 years. Stable in anhydrous DMSO at -80°C for up to 6 months.
Biosafety Level: Not applicable (BSL-1)
References: 1.Kulke, M., et al., Endocr. Relat. Cancer, 2014; 21: 705-714. 2.Margolis, K.G. et al., Gut, 2014; 63(6):928-37.
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