Formulation: A crystalline solid
Formal Name: N-[4-[4-(4-morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide
Purity: ≥98%
Formula Markup: C27H29N5O4
Formula Weight: 487,6
Shelf life (days): 730
CAS Number: 927878-49-7
Notes: TFC 007 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50 = 0.083 µM).{20048} It is selective for H-PGDS over lipocalin PGDS (L-PGDS) and microsomal PGE2 synthase (mPGES) at 100 µM. It is also selective for H-PGDS over COX-1, COX-2, 5-lipoxygenase (5-LO), leukotriene C4 (LTC4) synthase, and thromboxane (TX) synthase, as well as the histamine H1 and cysteinyl leukotriene 1 (CysLT1) receptors, at 10 µM. TFC 007 (30 mg/kg) inhibits antigen-induced increases in the production of PGD2 (Item No. 12010) in nasal cavity lavage fluid and reduces nasal blockage in a guinea pig model of allergic rhinitis.
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