TG2-179-1, CAS 1135023-19-6

Formulation: A solid

Formal Name: 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]thio]-N-[3-cyano-4-(4-fluorophenyl)-5-methyl-2-thienyl]-acetamide

Purity: ≥95%

Formula Markup: C22H14ClFN4O2S2

Formula Weight: 485

Shelf life (days): 1095

CAS Number: 1135023-19-6

Notes: TG2-179-1 is an inhibitor of BRCA1-associated protein 1 (BAP1).{67411} It inhibits the deubiquitinase activity of BAP1 in a cell-free assay when used at concentrations ranging from 25 µM to 1.5 mM. TG2-179-1 is cytotoxic against a panel of eight colon cancer cell lines (IC50s = 4.48-7.52 µM). In vivo, TG2-179-1 (10 and 30 mg/kg) reduces tumor volume in an HCT116 colon cancer mouse xenograft model.

• SKU: CAY38874-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38874-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK