TH-1760, CAS 2567914-01-4

Formulation: A solid

Formal Name: 6-[[4-(1H-indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3H)-benzoxazolone

Purity: ≥95%

Formula Markup: C20H18N4O5S

Formula Weight: 426,4

Shelf life (days): 1460

CAS Number: 2567914-01-4

Notes: TH-1760 is an inhibitor of nucleotide triphosphate diphosphatase NUDT15 (IC50 = 25 nM).{66717} It is selective for NUDT15 over a panel of additional Nudix family hydrolases and nucleotide pyrophosphatases at 100 µM, as well as a panel of 44 kinases at 10 µM. TH-1760 enhances thiopurine-induced cell death in NB4 and HL-60 cancer cells in a NUDT15-dependent manner.

• SKU: CAY40469-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40469-5
• Package Unit: 5 mg
• Quantity Unit: STK