Formulation: A solution in dichloromethane
Formal Name: (1aS,4aS,8aS)-1,1a,4,4a,5,6,7,8-octahydro-2,4a,8,8-tetramethyl-cyclopropa[d]naphthalene
Purity: ≥85%
Formula Markup: C15H24
Formula Weight: 204,4
Shelf life (days): 730
CAS Number: 470-40-6
Notes: Thujopsene is a sesquiterpene that has been found in T. dolabrata and has diverse biological activities.{65140,36906,65141,47402,65142} It inhibits the Na+/K+-ATPase (IC50 = 25.9 µg/ml) and cytochrome P450 (CYP) isoform CYP2B6 (Ki = 0.8 µM).{65140,36906} Thujopsene is active against Gram-positive and Gram-negative bacteria, including S. aureus, M. luteus, and S. typhimurium (MICs = 25-50 µg/ml).{65140} It inhibits antigen-induced β-hexosaminidase release from IgE-sensitized RBL-2H3 mast cells (IC50 = 25.1 µM) and is cytotoxic to A549 non-small cell lung cancer (NSCLC) cells with an LC50 value of 35.27 µg/ml.{65141,47402} Thujopsene induces mortality in the mites D. farniae and T. putrescentiae (LC50s = 9.82 and 10.92 µg/cm2, respectively).{65142}
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