Formulation: A solid
Formal Name: (3β,5β,25S)-spirostan-3-yl β-D-galactopyranoside
Purity: ≥98%
Formula Markup: C33H54O8
Formula Weight: 578,8
Shelf life (days): 1460
CAS Number: 68422-00-4
Notes: Timosaponin AI is a steroidal saponin that has been found in A. asphodeloides and has diverse biological activities.{64674,64675,64676} It is also a metabolite of timosaponin AIII (Item No. 22236).{64677} Timosaponin AI inhibits 5-lipoxygenase (5-LO), COX-2, and dipeptidyl peptidase 4 (DPP-4; IC50s = 3.29, 36.43, and 33.25 µM, respectively).{64674,64675} It reduces total cholesterol and triglyceride levels in 3T3-L1 differentiated adipocytes and increases glucose consumption in insulin-resistant BNL CL.2 mouse embryonic liver cells stimulated with insulin.{64675} Timosaponin AI is cytotoxic to NRK rat kidney epithelial and MOLM-13 acute myeloid leukemia (AML) cells (EC50s = 0.12 and 0.22 mM, respectively).{64676}
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