TK05, CAS 1245734-61-5

Formulation: A solid

Formal Name: 5-[[5-[(4-chlorophenyl)(cyclopropylmethyl)amino]-2-pyridinyl]carbonyl]-2-(4-methoxybenzoyl)-benzoic acid

Purity: ≥95%

Formula Markup: C31H25ClN2O5

Formula Weight: 541

Shelf life (days): 1460

CAS Number: 1245734-61-5

Notes: TK05 is an inhibitor of leukotriene C4 (LTC4) synthase (IC50 = 95 nM).{31499} It is selective for LTC4 synthase over microsomal prostaglandin E synthase-1 (mPGES-1), microsomal glutathione S-transferase 2 (GST2), and 5-lipoxygenase (5-LO) at 10 µM. TK05 (1 µM) inhibits LTC4 synthase in Mono-Mac-6 leukemia cells and isolated human eosinophils, monocytes, and platelets but not cord blood-derived mast cells. In vivo, TK05 (0.12 and 6 mg/kg) prevents zymosan A-induced increases in peritoneal fluid levels of LTE4 and LTB4 in mice.

• SKU: CAY19793-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 19793-1
• Package Unit: 1 mg
• Quantity Unit: STK