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Biological Activity: Tranylcypromine inhibits LSD1 with an IC50 value of 20.7 µM and a Ki value of 242.7 µM. It also irreversibly inhibits MAO A and MAO B with IC50 values of 2.3 and 0.95 µM and Ki values of 101.9 and 16 µM, respectively.
CAS Number: 13492-01-8
Description: Tranylcypromine (2-PCPA) is an irreversible inhibitor of LSD1 histone demethylase and monoamine oxidases (MAO). The inhibitor targets monoamine oxidases A and B and has been used as a chemical scaffold to design new demethylase inhibitors. Tranylcypromine has been shown to increase Histone H3 lysine 4 (H3K4) methylation in P19 embryonal carcinoma cell.
Format: A white to off white solid
Purity: ≥98% by HPLC
Solubility: Soluble in water (25 mg/ml).
Storage Stability: Store solid form at +4°C. Hygroscopic. Solid form is stable at least 12 months from date of receipt, when stored as directed. Aqueous solutions are less stable; we recommend preparing and using stock solutions the same day.
Warnings: Hygroscopic. Protect from moisture. Protect from light.
Biosafety Level: Not applicable (BSL-1)
References: 1. Schmidt, D.M.Z., and McCafferty, D.G. et al. Biochemistry 46:4408-4416 (2007)
2. Yang, M., et al. Biochemistry 46:8058-65(2007)Application Reference(s):Schooley, A., et al. J Cell Sci. 2015 Sep 15;128(18):3466-77. doi: 10.1242/jcs.173013. The lysine demethylase LSD1 is required for nuclear envelope formation at the end of mitosis (2015)
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