Trichostatin A (TSA) , CAS 58880-19-6

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Biological Activity: TSA inhibited proliferation of eight breast carcinoma cell lines with mean ±SD IC50 of 124.4 ± 120.4 nM (range of 26.4 nM -308.1 nM). HDAC inhibitory activity of TSA was similar in all cell lines with mean ± SD IC50 of 2.4 ± 0.5 nM (range of 1.5 nM-2.9 nM), and TSA treatment resulted in pronouncing histone H4 hyperacetylation. TSA inhibited HDAC3 with IC50 of 0.9 nM using the BPS Bioscience Fluorogenic HDAC Assay Kit (Cat. #50061).

CAS Number: 58880-19-6

Description: Trichostatin A (TSA) is an antifungal antibiotic with cytostatic and differentiating properties in mammalian cell culture.

Format: White to beige powder.

Purity: ≥98% by HPLC

Solubility: Soluble to 10 mM in ethanol and to 50 mM in DMSO

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Biosafety Level: Not applicable (BSL-1)

References: Festuccia, C. et al. Endocr Relat Cancer 2009;16: 401-413

• SKU: BPS27102
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 27102
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK