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Biological Activity: Tubacin reversibly inhibits α-tubulin deacetylation activity of HDAC6 (IC50 = 4 nM) The IC50 for other HDACs is 1000-fold higher, making tubacin both more selective and more potent than Tubastatin A, which also inhibits HDAC8.
CAS Number: 1350555-93-9
Description: Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor . Tubacin does not inhibit HDAC6 histone deacetylase activity; instead, tubacin is specific for the tubulin deacetylase activity of HDAC6. It reversibly inhibits α-tubulin deacetylation in mammalian cells and increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.
Purity: ≥98% by HPLC
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: HDAC6
Biosafety Level: Not applicable (BSL-1)
References: 1. Aldana-Masangkay GI, et al. Leuk Lymphoma. 2011 Aug;52(8):1544-55.
2. Kawada J, et al. J Biol Chem. 2009 Jun 19;284(25):17102-9.
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