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Biological Activity: UNC0224 inhibits G9a with an IC50 value of 15 nM. It has been shown to inhibit GLP with assay-dependent IC50 values of 20-58 nM.
CAS Number: 1197196-48-7
Description: UNC0224 is a potent and selective inhibitor of G9a, a histone methyltransferase (HMT). It also inhibits GLP, a closely-related H3K9 HMT, but is more than 1,000-fold selective against SET7/9 and SET8.
Format: A crystalline solid
Purity: ≥98% by HPLC
Solubility: Soluble in DMSO, DMF and ethanol, purged with an inert gas. Solubility in DMSO and DMF is approximately 2 mg/ml, and solubility in ethanol is ~15 mg/ml.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Tachibana, M., et al., Genes Dev. 2002; 16:1779-1791.
2. Wagschal, A., et al., Mol. Cell. Biol. 2008; 28(3):1104-1113.
3. Thomas, L.R., et al., J. Immunol. 2008; 181:485-493.
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