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Biological Activity: UNC1215 has been shown to inhibit L3MBTL1 with an IC50 of 1.0 µM.
Description: UNC 1215 is a methyl-lysine inhibitor. UNC1215 inhibits L3MBTL3 with 50x more potency than other MBT family members.
Format: A white solid
Purity: ≥95% by HPLC
Solubility: Soluble in water (> 10 mM)
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Store aqueous solutions inaliquots at -80°C for up to one month.
Warnings: Hygroscopic. Protect from moisture.
Biosafety Level: Not applicable (BSL-1)
References: James, L.I., et al.Nat Chem Biol. 2013 Mar;9(3):184-91.