Formulation: A solid
Formal Name: 2-chloro-N-[4-chloro-3-(2,3-dihydro-1H-isoindol-5-yl)phenyl]-4-(methylsulfonyl)-benzamide
Purity: ≥98%
Formula Markup: C22H18Cl2N2O3S
Formula Weight: 461,4
Shelf life (days): 1460
CAS Number: 2931509-15-6
Notes: USP28-IN-4 is an inhibitor of ubiquitin-specific protease 28 (USP28; IC50 = 0.04 µM).{51920} It is selective for USP28 over USP2, USP7, USP8, USP9x, ubiquitin C-terminal hydrolase L3 (UCH-L3), and UCH-L5 at 5 µM but does inhibit USP25 at the same concentration. USP28-IN-4 reduces the levels of the USP28 substrate c-Myc in HCT116 and LS 174T colorectal cancer cells when used at concentrations of 80 and 60 µM, respectively, and reduces the viability of the same cells (IC50s = 38.11 and 24.3 µM, respectively). It also reduces the levels of the USP25 substrate tankyrase 1/2 in HCT116 and LS 174T cells.
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