UT-11

Formulation: A solid

Formal Name: (R)-1-(5,6-dichlorobenzo[d]thiazol-2-yl)-N-(tetrahydrofuran-3-yl)piperidine-4-carboxamide

Purity: ≥98%

Formula Markup: C17H19Cl2N3O2S

Formula Weight: 400,3

Shelf life (days): 1095

Notes: UT-11 is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1).{72009} It inhibits PGE2 production in both SK-N-AS human neuroblastoma and BV-2 mouse microglial cells (IC50s = 0.1 and 2 µM, respectively). UT-11 (10 mg/kg, i.p.) reduces LPS-induced increases in a variety of cytokines, including chemokine (C-C motif) ligand 2 (CCL2), IL-6, and TNF-α, in the mouse hippocampus, but not kidney, without affecting the mRNA expression of Cox2.

• SKU: CAY38580-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38580-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK