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Biological Activity: Valproic acid inhibits Class I HDACs with an IC50 of ~ 2 mM.
CAS Number: 1069-66-5
Description: Valproic acid inhibits histone deacetylases (HDACs), in particular Class I HDACs. It is an analog of the natural fatty acid valeric acid. Valproic acid also inhibits GSK3 and depletes cellular inositol-1,4,5-triphosphate. It can have strong effects on stem cell differentiation and self-renewal, and it shows promise in treating cancer and Alzheimer's disease.
Format: A crystalline solid
Purity: ≥95% by HPLC
Solubility: Soluble in ethanol, DMSO and dimethyl formamide (DMF). Solubility in ethanol is 30 mg/ml and 5 mg/ml in DMSO and DMF. For organic solvent-free aqueous solutions, prepare by directly dissolving the crystalline compound in aqueous buffers.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Jung, G., et al., BMC Cell Biol. 2008; 9(66).
2. Bug, G., et al., Cancer Res. 2005; 65(7): 2537 - 2541.
3. Gottlicher, M., et al., EMBO J. 2001; 20(24): 6969 - 6978.
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