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Background: Vardenafil is frequently used in the treatment erectile dysfunction, and is the active ingredient in Levitra. It has been reported to significantly enhance the SNP-induced, ACh-induced and transmural electrical stimulation-induced relaxation of human trabecular smooth muscle. Vardenafil has been revealed to increase the amount of cGMP in human corpus cavernosum.
Biological Activity: Vardenafil has shown a greater selective inhibition towards PDE5 (IC50 = 0.7 nM) vs. PDEs from bovine, with the IC50 values of 180 nM, >10 µM, 2.5 µM, 4 µM and 11 nM for PDE1, PDE2, PDE3, PDE4 and PDE6, respectively. It is shows selectivity for PDE5 vs. over 300-fold relative to PDE11 and over 1000-fold relative to PDEs 8, 9, and 10.
CAS Number: 224785-90-4
Description: Vardenafil is a potent and selective inhibitor of phosphodiesterase type5 (PDE5) with the IC50 value of 0.7 nM in enzymatic assay in vitro.
Format: nearly colourless solid
Solubility: Soluble in ethanol or 0.1M HCl. Only slightly soluble in water.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: PDE5
Biosafety Level: Not applicable (BSL-1)
References: Saenz de Tejada I., et al. Int J Impot Res. 2001 Oct;13(5):282-90.
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