Vimseltinib, CAS 1628606-05-2

Formulation: A solid

Formal Name: 3-methyl-2-[(1-methylethyl)amino]-5-[6-methyl-5-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]-4(3H)-pyrimidinone

Purity: ≥95%

Formula Markup: C23H25N7O2

Formula Weight: 431,5

Shelf life (days): 1460

CAS Number: 1628606-05-2

Notes: Vimseltinib is an inhibitor of colony stimulating factor 1 receptor (CSF1R; IC50 = 3.7 nM).{67444} It is selective for CSF1R over FMS-related tyrosine kinase 3 (FLT3), PDGFRα, PDGFRβ, and KIT (IC50s = >3,300, 436, 2,300, and 476 nM, respectively). Vimseltinib inhibits the proliferation of M-NFS-60 leukemia cells (IC50 = 18 nM). It inhibits CSF1-induced CFS1R autophosphorylation in THP-1 cells (IC50 = 27 nM) and CSF1- and RANKL-induced osteoclast differentiation (IC50 = 9.3 nM).

• SKU: CAY38783-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38783-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK