Formulation: A solid
Formal Name: 2,3-dihydro-2-[1-(phenylmethyl)-4-piperidinyl]-4H-1-benzothiopyran-4-one
Purity: ≥98%
Formula Markup: C21H23NOS
Formula Weight: 337,5
Shelf life (days): 1460
CAS Number: 1204401-49-9
Notes: WQ 1 is an antagonist of sigma non-opioid intracellular receptor 1 (σ1 receptor; Ki = 0.01 nM).{68691} It is selective for the σ1 receptor over the σ2 receptor and dopamine transporter (DAT; Kis = 295.12 and 1,585 nM, respectively). WQ 1 (10 µM) decreases proliferation of MCF-7 breast cancer and MCF-7/adr multidrug-resistant breast cancer cells.{68692} It induces cell cycle arrest at the G0/G1 phase in MCF-7 and MCF-7/adr cancer cells and apoptosis in MCF-7/adr cancer cells. WQ 1 (1 mg/kg) increases the duration of morphine-induced latency to tail withdrawal in the tail-flick test in mice when administered 30 minutes prior to the test. WQ 1 (3 or 7 mg/kg) reduces stress-induced food consumption in rats.{68691}
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