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Biological Activity: XAV939 inhibited TNKS1 and TNKS2 with IC50 of 4.6 nM and 1.68 nM, respectively using BPS Bioscience TNKS1 Assay Kit (Cat. # 80564) and TNKS2 Assay Kit (Cat. # 80566).
CAS Number: 284028-89-3
Description: XAV 939 is a small molecule and selective Wnt pathway transcription factor - catenin-mediated transcription inhibitor and axin stabilizing agent. It stimulates beta-catenin degradation by stabilizing axin, the concentration-limiting component of the destruction complex and stabilizes axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 (TNKS1) and tankyrase 2 (TNKS2).
Format: White to beige powder.
Purity: ≥99% by HPLC
Solubility: Soluble in DMSO at 25 mg/ml.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: Huang, SM. et al. Nature. 2009 Oct 1; 461(7264):614-20.
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