Formulation: A crystalline solid
Formal Name: 5,11-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Purity: ≥98%
Formula Markup: C24H27N7O2
Formula Weight: 445,5
Shelf life (days): 1460
CAS Number: 1234480-46-6
Notes: XMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2) with an IC50 value of 1.9 μM in HEK293T cells expressing human TNK2.{37179} It is selective for TNK2 over a panel of approximately 100 kinases with >90 and 50s = 0.1-77 nM) commonly found in leukemias but has no effect on cells expressing wild-type TNK2 (IC50 = >1 μM).