YO-01027 (GMP), CAS 209984-56-5

Product Description: YO-01027 (Dibenzazepine) (GMP) is YO-01027 (HY-13526) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potent γ-secretase inhibitor[1][2].

Applications: Neuroscience-Neurodegeneration

Formula: C26H23F2N3O3

References: [1]Ichida JK, et al. Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol. 2014 Aug;10(8):632-639. /[2]Wu J, et al. Dibenzazepine promotes cochlear supporting cell proliferation and hair cell regeneration in neonatal mice. Cell Prolif. 2020 Sep;53(9):e12872. /[3]Groth C, et al. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Mol Pharmacol. 2010 Apr;77(4):567-74.

CAS Number: 209984-56-5

Molecular Weight: 463.48

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Notch;γ-secretase

• SKU: MEXHY-13526G-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-13526G-0
• Package Unit: Get quote
• Quantity Unit: STK