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Amino Acid Sequence: Z-Asp(OMe)-Gln-Met-Asp(OMe)-CH?F
Background: Z-DQMD-FMK is a potent cell-permeable inhibitor of caspase-3. Researchers have shown that expression of a short peptide of 15 amino acids, including DQMD leads to abrogation of the apoptotic cascade, and treatment of cells, expressing the DQMD peptide with two apoptosis inducers, etoposide and sodium nitroprusside blocks cell death by apoptosis. Stable expression of the DQMD peptide leads to protection of cells, following induction of apoptosis and to the outgrowth and enrichment of resistant cell colonies.
Biological Activity: We recommend using 2-10 µM for inhibiting caspase activity in cell culture. The optimal dose may vary for different cells and culture conditions.
Description: Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3. Inhibits MG 132-induced small cell lung cancer cell death in vitro. Z-DQMD-FMK can be used for both in vitro and in vivo studies--see note for using this product in vitro.
Purity: ≥88% by HPLC
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: Caspase 3
Biosafety Level: Not applicable (BSL-1)
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