Formulation: A crystalline solid
Formal Name: 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid
Purity: ≥98%
Formula Markup: C12H20N4O7
Formula Weight: 332,3
Shelf life (days): 1460
CAS Number: 139110-80-8
Notes: Zanamivir is an inhibitor of influenza neuraminidase.{62611} It inhibits neuraminidase activity in clinical isolates of influenza A subtypes H1N1 and H3N2 and influenza B (geometric mean IC50s = 0.73, 1.64, and 11.21 nM, respectively). Zanamivir inhibits replication of influenza A and B in isolated human respiratory epithelial cells (EC90s = <0.01 mg/L and 0.25-0.54 mg/L, respectively).{62612} It reduces lung viral titers in mice infected with influenza A or B when administered intranasally at a dose of 0.4 mg/kg. Formulations containing zanamivir have been used in the prevention and treatment of influenza infection.
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