ZK 824859, CAS 2254001-81-3

Formulation: A solid

Formal Name: 2-[[6-[[3′-(aminomethyl)[1,1′-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-butanoic acid

Purity: ≥98%

Formula Markup: C22H20F2N2O4

CAS Number: 2254001-81-3

Notes: ZK 824859 is an inhibitor of urokinase-type plasminogen activator (uPA; IC50s = 79 and 410 nM for the human and mouse proteins, respectively).{66670} It is selective for human uPA over human tissue-type plasminogen activator (tPA) and plasmin (IC50s = 1,580 and 1,330 nM, respectively) but not selective for mouse uPA over mouse tPA and plasmin (IC50s = 910 and 1,600 nM, respectively). ZK 824859 (25 or 50 mg/kg per day) reduces the incidence of limb weakness and paralysis in mice in a model of experimental autoimmune encephalomyelitis (EAE).

• SKU: CAY37789-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37789-25
• Package Unit: 25 mg
• Quantity Unit: STK