Formulation: A solid
Formal Name: 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-4S-(phenylthio)-L-proline
Purity: ≥95%
Formula Markup: C15H19NO3S2
Formula Weight: 325,4
Shelf life (days): 1460
CAS Number: 75176-37-3
Notes: Zofenoprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 8 nM for the rabbit lung enzyme) and an active metabolite of the prodrug zofenopril (Item No. 29525).{52244,52243} It inhibits angiotensin I- or bradykinin-induced contractions of isolated guinea pig ileum (EC50s = 3 and 1 nM, respectively).{52244} Zofenoprilat (10 nM) decreases basal endothelin-1 secretion and nitric oxide (NO) production, as well as prevents TNF-α-induced increases in reactive oxygen species (ROS) and decreases in glutathione (GSH) levels, in human umbilical vein endothelial cells (HUVECs).{16847} It protects primary human cardiac microvascular endothelial cells against doxorubicin-induced cytotoxicity when used at a concentration of 10 µM.{66430} Zofenoprilat (10 µM) also increases hydrogen sulfide (H2S) production in, and adhesion, migration, and proliferation of, HUVECs.{66431} It reduces end diastolic pressure and lactate dehydrogenase (LDH) release in a Langendorff isolated perfused rat heart model of ischemia-reperfusion injury when used at a concentration of 400 µM.{52243}
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