Product Description: 7ACC1 (DEAC; Coumarin D 1421; D 1421) can selectively interfere with lactate flux in the tumor microenvironment and inhibit the influx of lactate in tumor cells expressing MCT1 and MCT4, but has no effect on lactate efflux.
Applications: Cancer-programmed cell death
Formula: C14H15NO4
References: [1]Draoui N, et al. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol Cancer Ther. 2014 Jun;13(6):1410-8.