Formulation: A crystalline solid
Formal Name: (3α,5β,7α,12α)- N-[2-[(3′,6′-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthen]-5-yl)amino]-2-oxoethyl]-3,7,12-trihydroxy-cholan-24-amide
Purity: ≥95%
Formula Markup: C46H54N2O10
Formula Weight: 794,9
Shelf life (days): 730
CAS Number: 168912-70-7
Notes: CGamF is a fluorescent probe for hepatic bile acid transport that is composed of cholic acid (Item No. 20250) conjugated via a glycylamino linkage to fluorescein.{51877,51879} It displays excitation/emission values of 492/515 nm, respectively, in aqueous solution at pH 7.4.{51879} CGamF fluorescence intensity increases as pH increases upon excitation at 495 nm but is pH-independent upon excitation at 440 nm. CGamF uptake by hepatocytes becomes sodium-dependent as CGamF concentration increases, with lower sodium levels resulting in reduced uptake.{51877,51879} CGamF has been used in the study of hepatic transporter-mediated drug interactions and toxicity in vitro.{51880,41878}
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