Product Description: Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite[1][2][3].
Applications: Cancer-programmed cell death
Formula: C26H21N3O3
References: [1]Markova SV, et al, Coelenterazine-dependent luciferases. Biochemistry (Mosc). 2015 Jun;80(6):714-32./[2]Lucas M, et al. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe: its usefulness in the assay of respiratory burst in neutrophils. Anal Biochem. 1992 Nov 1;206(2):273-7./[3]Pichler A, et al. In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein. Clin Cancer Res. 2005 Jun 15;11(12):4487-94./[4]Volk-Draper LD, et al. Novel model for basaloid triple-negative breast cancer: behavior in vivo and response to therapy. Neoplasia. 2012 Oct;14(10):926-42.
CAS Number: 55779-48-1
Molecular Weight: 423.46
Compound Purity: 98.94
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)/Ethanol : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Reactive Oxygen Species
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