Product Description: Coumberone is a metabolic fluorogenic probe, and isoform-selective substrate for all AKR1C isoforms. Coumberone can be reduced by all four members of the AKR1C family to its fluorescent alcohol coumberol. Coumberone can be used for the research of AKR1C[1][2].
Formula: C22H19NO3
References: [1]Jamieson SM, et al. A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells. Biochem Pharmacol. 2014;88(1):36-45./[2]Halim M, et al. Imaging induction of cytoprotective enzymes in intact human cells: coumberone, a metabolic reporter for human AKR1C enzymes reveals activation by panaxytriol, an active component of red ginseng. J Am Chem Soc. 2008;130(43):14123-14128.
CAS Number: 878019-47-7
Molecular Weight: 345.39
Compound Purity: 99.63
Research Area: Cancer
Solubility: DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 70°C)
Target: Fluorescent Dye
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