Product Description: Hoechst 34580 tetrahydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution[1].
Applications: Neuroscience-Neurodegeneration
Formula: C27H33Cl4N7
References: [1]Thai NQ, et al. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study. J Comput Aided Mol Des. 2016 Aug;30(8):639-50.
CAS Number: 2310135-08-9
Molecular Weight: 597.41
Compound Purity: 99.77
Research Area: Neurological Disease
Solubility: H2O : 2.67 mg/mL (ultrasonic)
Target: Amyloid-β
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