Product Description: IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS)-Akt-mTOR pathway[1].
Formula: C58H82BrClN4O6
References: [1]Yinghui Huang, et al. Identification of a fluorescent small-molecule enhancer for therapeutic autophagy in colorectal cancer by targeting mitochondrial protein translocase TIM44. Gut. 2018 Feb;67(2):307-319.
CAS Number: 2374274-85-6
Molecular Weight: 1046.65
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Apoptosis;Autophagy