Product Description: SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe3+ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM)[1].
Formula: C22H23N5O4
References: [1]Yan X, et al. Novel imidazo[1,2,4] triazole derivatives: Synthesis, fluorescence, bioactivity for SHP1. Eur J Med Chem. 2024 Feb 5;265:116027.
CAS Number: 2956720-62-8
Molecular Weight: 421.45
Research Area: cancer
Solubility: 10 mM in DMSO
Target: Fluorescent Dye;Phosphatase