Takeda-103A, CAS 865609-72-9

Formulation: A solid

Formal Name: N-[(2,6-difluorophenyl)methyl]-3-[[[4-propyl-5-(4-pyrimidinyl)-4H-1,2,4-triazol-3-yl]methyl]amino]-benzamide

Purity: ≥98%

Formula Markup: C24H23F2N7O

Formula Weight: 463,5

Shelf life (days): 1460

CAS Number: 865609-72-9

Notes: Takeda-103A is an inhibitor of G protein-coupled receptor kinase 2 (GRK2).{51784} It selectively inhibits phosphorylation of bovine rod outer segments by GRK2 (IC50 = 54 nM) over phosphorylation by GRK1 and GRK5 at concentrations up to 125 µM. Takeda-103A also inhibits phosphorylation of bovine rod outer segments by GRK2 containing various mutations, including GRK2L271M, GRK2Y206S, GRK2I197L, and GRK2L235G (IC50s = 24, 55, 106, and 180 nM, respectively).

• SKU: CAY41027-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41027-1
• Package Unit: 1 mg
• Quantity Unit: STK