Formulation: A solid
Formal Name: 4-[[[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]amino]carbonyl]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]-1-piperidineacetamide
Purity: ≥95%
Formula Markup: C40H52N8O10S2
Formula Weight: 869
Shelf life (days): 1460
CAS Number: 2139287-33-3
Notes: THAL-SNS-032 is a proteolysis-targeting chimera (PROTAC) containing the cyclin-dependent kinase 2 (Cdk2), Cdk7, and Cdk9 inhibitor SNS-032 (Item No. 17904) linked to a cereblon (CRBN) binding moiety.{58685} It selectively induces degradation of Cdk9 over Cdk1, Cdk2, and Cdk7 in MOLT-4 cells when used at a concentration of 250 nM. THAL-SNS-032 inhibits human cytomegalovirus (HCMV) replication in infected human foreskin fibroblasts (HFFs; EC50s = 0.025 µM).{68801} It also inhibits viral replication in murine CMV-infected mouse embryonic fibroblasts (MEFs; EC50 = 0.22 µM).
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