TP-060, CAS 2601393-20-6

Formulation: A solid

Formal Name: 4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydro-2-[4-(1-hydroxy-1-methylethyl)phenyl]-1H-pyrrolo[3,4-c]pyridin-1-one

Purity: ≥98%

Formula Markup: C24H20F4N2O3

Formula Weight: 460,4

Shelf life (days): 1460

CAS Number: 2601393-20-6

Notes: TP-060 is an inhibitor of UDP-glucose ceramide glucosyltransferase (IC50 = 0.031 µM).{51775} It is selective for UDP-glucose ceramide glucosyltransferase over human ether-a-go-go (hERG) at 10 µM but also inhibits serotonin receptors (5-HT; IC50 = 0.31 µM). In vivo, TP-060 (30 mg/kg per day) decreases the cerebral cortex and serum levels of glucosylceramide and glucosylsphingosine in a Gba D409V transgenic mouse model of Gaucher disease.{51774}

• SKU: CAY41127-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41127-5
• Package Unit: 5 mg
• Quantity Unit: STK