Formulation: A solution in ethanol
Formal Name: N-[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]-6,6-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-25-hydroxy-8-oxo-4,11,14,17,20,23-hexaoxa-7-azapentacosanamide
Purity: ≥95%
Formula Markup: C75H134N10O35
Formula Weight: 1735,9
Shelf life (days): 730
CAS Number: 1953146-81-0
Notes: Tri-GalNAc COOH is an intermediate in the synthesis of lysosome-targeting chimeras (LYTACs) containing a triad of the galactose amino sugar derivative GalNAc (Item No. 31728) connected by acyl-amino chains to an ether linker with a terminal carboxylic acid that can be functionalized with antibodies or biotin.{72391} It has been used in the synthesis of LYTACs functionalized with anti-EGFR antibodies that reduce EGFR levels without affecting total protein levels in HepG2 hepatocellular carcinoma cells.
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