119-23, CAS 2953044-98-7

Formulation: A solution in ethanol

Formal Name: 9Z-octadecenoic acid, 6-[[3-(dimethylamino)propyl][(9Z)-1-oxo-9-octadecen-1-yl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl ester

Purity: ≥95%

Formula Markup: C58H105N3O4

Formula Weight: 908,5

Shelf life (days): 730

CAS Number: 2953044-98-7

Notes: 119-23 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.{67909} LNPs containing 119-23 and encapsulating an mRNA reporter show greater intramuscular transfection efficacy compared to LNPs containing the ionizable cationic lipids SM-102 (Item No. 33474) or DLin-MC3-DMA (Item No. 34364) in mice. 119-23-containing LNPs accumulate in mouse hepatic and splenic immune cells to a greater extent than SM-102-containing LNPs. LNPs containing 119-23 and encapsulating mRNA encoding human erythropoietin (hEPO) increase serum hEPO levels in mice.

• SKU: CAY41386-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41386-5
• Package Unit: 5 mg
• Quantity Unit: STK