Formulation: A solution in ethanol
Purity: ≥95%
Formula Markup: C75H139N3O16S4
Formula Weight: 1467,2
Shelf life (days): 730
CAS Number: 1857340-78-3
Notes: 4A3-SC8 is an ionizable cationic lipid (pKa = 6.66) and a dendrimer that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA, mRNA, single-guide RNA (sgRNA), ssDNA, and PEGylated BODIPY dyes.{66425,51254,66428,68875} LNPs containing 4A3-SC8 and encapsulating siRNA targeting Factor VII selectively accumulate in the liver and decrease hepatic Factor VII activity in mice.{66425} Intratumoral administration of LNPs containing 4A3-SC8 and encapsulating homologous double-strand repair (HDR) elements correct the DNA encoding GFP with a tyrosine-to-histidine mutation at position 66 (GFPY66H) in a HEK293 mouse xenograft model.{66428} Intravenous administration of LNPs containing 4A3-SC8 and encapsulating an mRNA reporter and a PEGylated BODIPY dye have been used for tumor imaging in mice.{68875}
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