Formulation: A solution in ethanol
Formal Name: tetrakis(8-methylnonyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate
Purity: ≥95%
Formula Markup: C59H115N3O8
Formula Weight: 994,6
Shelf life (days): 730
CAS Number: 2322290-93-5
Notes: 306Oi10 is a branched-chain ionizable cationic lipidoid (pKa = 6.4) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.{67038} LNPs containing 306Oi10 and encapsulating an mRNA reporter increase luminescence in the livers and spleens in mice to a greater extent than LNPs containing MC3 (DLin-MC3-DMA; Item No. 34364) or C12-200 (Item No. 36699).{37039} LNPs containing 306Oi10 and encapsulating an mRNA reporter selectively accumulate in hepatocytes, and to a lesser extent in Kupffer and endothelial cells, in mice. LNPs containing 306Oi10 and encapsulating mRNA encoding erythropoietin (EPO) increase serum levels of EPO in mice.
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