Formulation: A solution in ethanol
Formal Name: 9-octadecenoic acid, 1,1′-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester
Purity: ≥95%
Formula Markup: C59H113NO5
Formula Weight: 916,5
Shelf life (days): 730
CAS Number: 2256087-35-9
Notes: CL4H6 is an ionizable cationic lipid (apparent pKa = 6.35) that has been used in the generation of lipid nanoparticles (LNPs) encapsulating siRNA for use in vivo.{65433} LNPs containing CL4H6 and encapsulating siRNA targeting mRNA encoding Factor VII decrease hepatic levels of Factor VII in mice. Intravenous administration of LNPs containing CL4H6 and encapsulating a reporter protein selectively accumulate in the liver, spleen, and tumors over the lungs and kidneys, as well as selectively accumulate in tumor-associated macrophages (TAMs) over tumor cells, neutrophils, and other leukocytes, in an OS-RC-2 renal cancer mouse xenograft model.{65434} LNPs containing CL4H6 and encapsulating siRNAs targeting mRNA encoding Stat3 and Hif-1α increase the levels of M1 macrophages in the tumor microenvironment and decrease tumor volume in the same model.{65434}
English
Deutsch
