Formulation: A solution in ethanol
Formal Name: N,N-dimethyl-2,2-di-(9Z,12Z)-9,12-octadecadien-1-yl-1,3-dioxolane-4-ethanamine
Purity: ≥98%
Formula Markup: C43H79NO2
Formula Weight: 642,1
Shelf life (days): 730
CAS Number: 1190197-97-7
Notes: DLin-KC2-DMA is an ionizable cationic lipid (apparent pKa = 6.7) that has been used in the formation of lipid nanoparticles (LNPs) encapsulating siRNA or plasmid DNA for use in vitro and in vivo.{62187,66839} LNPs containing DLin-KC2-DMA selectively accumulate in the liver after intravenous or intramuscular administration in mice or localize to the retinal pigment epithelium and Müller glia after subretinal administration.{66839,66840} DLin-KC2-DMA-containing LNPs encapsulating siRNA targeting F7 mRNA, which encodes Factor VII, reduce serum Factor VII levels in mice.{62187} Intravenous administration of DLin-KC2-DMA-containing LNPs encapsulating siRNA targeting AR mRNA, which encodes the androgen receptor, decrease serum prostate-specific antigen (PSA) and tumor androgen receptor levels in an LNCaP prostate cancer mouse xenograft model.{62188}
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