Formulation: A solution in ethanol
Formal Name: 9-[4-(dimethylamino)-1-oxobutoxy]-heptadecanedioic acid, 1,17-di-(2Z)-2-nonen-1-yl ester
Purity: ≥95%
Formula Markup: C41H75NO6
Formula Weight: 678
Shelf life (days): 730
CAS Number: 1351586-50-9
Notes: L-319 is an ionizable cationic (pKa = 6.38) and biodegradable lipid derivative of DLin-MC3-DMA (Item No. 34364) that has been used in the formation of lipid nanoparticles (LNPs).{61765} LNPs containing L-319 and encapsulating siRNA encoding Factor VII (FVII) reduce serum levels of FVII in mice. LNPs containing L-319 in combination with cKK-E12 (Item No. 36700) and encapsulating varicella-zoster virus (VZV) mRNA encoding glycoprotein E (gE) increase the lymph node and spleen levels of CD11c+CD80+ and CD11c+CD86+ cells and total serum IgG titers in mice, as well as decrease the number of VZV-induced rashes and the epithelial levels of VZV DNA, in a guinea pig model of VZV-induced shingles.{49896}
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