Formulation: A solution in ethanol
Formal Name: (3α,5β)-N-[2-(didecylamino)ethyl]-3-hydroxy-cholan-24-amide
Purity: ≥98%
Formula Markup: C46H86N2O2
Formula Weight: 699,2
Shelf life (days): 365
CAS Number: 2768690-22-6
Notes: LC10 is a lipidoid derivative of the secondary bile acid lithocholic acid (Item No. 20253) that contains two 10-carbon alkyl chains.{66148} It has been used in the generation of self-assembling skin-permeable lipid nanoparticles (LNPs). LC10 LNPs inhibit the proliferation of normal human epidermal keratinocytes (NHEKs) when used at a concentration of 100 nM and reduce the levels of TNF-α, IL-17, and IL-23 in human peripheral blood mononuclear cells (PBMCs) at 50, 100, and 200 nM. Topical application of LC10 LNPs (10 mg/kg) reduces psoriatic-like plaques and reverses weight loss induced by imiquimod (Item No. 14956) in a mouse model of psoriasis.
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