Formulation: A solution in ethanol
Formal Name: 5-(dimethylamino)-pentanoic acid, (6Z)-1,2-di-(4Z)-4-decen-1-yl-6-dodecen-1-yl ester
Purity: ≥95%
Formula Markup: C39H73NO2
Formula Weight: 588
Shelf life (days): 365
CAS Number: 1450888-71-7
Notes: Lipid CL1 is an ionizable cationic trialkyl lipid (pKa = 6.3) that has been used in the formation of lipid nanoparticles (LNPs) for delivering mRNA in vivo.{72476,64931} LNPs containing lipid CL1 and encapsulating mRNA encoding human erythropoietin (EPO) increase blood EPO protein levels in mice.{64931} LNPs containing lipid CL1 and encapsulating mRNA encoding a reporter protein increase reporter expression in the liver to a greater extent than LNPs containing the ionizable lipids DLin-DMA (Item No. 36701), KC2 (DLin-KC2-DMA; Item No. 34363), MC3 (DLin-MC3-DMA; Item No. 34364), or LP-01 (Item No. 37278) in mice.{72476} LNPs containing lipid CL1 and encapsulating mRNA encoding influenza A hemagglutinin (HA) increase anti-HA IgG antibody titers to a greater extent than LNPs containing the ionizable cationic lipid SM-102 (Item No. 33474) in a mouse model of HA vaccination.
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