Lipid III-45, CAS 2096984-25-5

Formulation: A solution in ethanol

Formal Name: 2-butyl-octanoic acid, 1,1′-[[(3-hydroxypropyl)imino]di-9,1-nonanediyl] ester

Purity: ≥98%

Formula Markup: C45H89NO5

Formula Weight: 724,2

Shelf life (days): 1095

CAS Number: 2096984-25-5

Notes: Lipid III-45 is an ionizable cationic lipid (pKa = 6.25).{67404} It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.{67404,67405,67406} LNPs containing lipid III-45 and encapsulating a luciferase mRNA reporter accumulate in liver and adipose tissue in mice.{67404,67405} LNPs containing lipid III-45 have been used to deliver an mRNA sequence encoding an antibody targeting the tumor-associated antigen and tight junction integral protein claudin-18 isoform 2 (claudin-18.2) to mice and reduce tumor volume in an MDA-MB-231 mouse xenograft model.{67406}

• SKU: CAY39243-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39243-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK